Basophil Activation Testing (BAT)

Basophil Activation Testing (BAT):

Our Basophil Activation Testing (BAT) measures the degree of degranulation following allergen stimulation, optimizing the management of food allergic patients. This functional assay provides precise and reliable insights into allergic responses, aiding in the effective diagnosis and treatment of food allergies. Here are key aspects of our Basophil Activation Testing (BAT):

1. Assessment of Basophil Response:
   • The BAT measures the activation and degranulation of basophils, which are critical in allergic reactions.
   • Markers include: Basophil Identification- IgE, CD123, CD193; Basophil Response- CD63, CD203c; and Lymphocyte Immune Phenotyping- CD3, CD4, CD8, CD16, CD20, CD45, CD45RO, CD56, CD294.
2. High Specificity and Sensitivity:
   • This assay is highly specific and sensitive, providing accurate detection of basophil activation in response to allergens.
   • The high level of specificity reduces the likelihood of false positives, ensuring reliable results.
3. Safety and Efficacy:
   • BAT offers a safe alternative to in vivo procedures, such as intradermal tests and allergen challenges, which can cause allergic reactions of unpredictable severity.
   • This test minimizes patient risk while providing valuable diagnostic information.
4. Optimizing Food Allergy Management:
   • The BAT helps in optimizing the management of food allergic patients by identifying specific allergens that trigger basophil activation.
   • The results guide targeted therapies such as oral food challenges or oral immunotherapy, improving patient outcomes.
5. Functional Assay Correlation:
   • The BAT correlates directly with histamine release, a key indicator of allergic reactions, providing a functional measure of basophil activation.
   • This correlation enhances the clinical relevance of the test results.
6. Contextual Interpretation:
   • The results of the BAT should be interpreted in the context of the patient’s clinical history and other food allergy testing results.
   • Our comprehensive analysis includes consultative insights to help clinicians make informed decisions about patient care.

By utilizing Basophil Activation Testing (BAT), we offer a precise, safe, and effective method for diagnosing and managing food allergies. This assay is an essential tool in our diagnostic services, enabling us to provide targeted and personalized treatment plans for our patients, ultimately improving their quality of life.