Type 2 Inflammation Biologic (Anti-IL-5) from GlaxoSmithKline (GSK).
Exdensur is a long-acting IL-5 monoclonal antibody dosed twice yearly (every 6 months) for severe eosinophilic asthma. The twice-yearly dosing interval is a meaningful convenience change compared to the every-4-week and every-8-week dosing of other IL-5 pathway biologics. It is FDA-approved as add-on maintenance treatment in patients 12 years and older with severe asthma and an eosinophilic phenotype.
Exdensur is FDA-approved for the following indications:
Exdensur is administered subcutaneously every six months, typically as an in-office injection.
The manufacturer offers a patient support program — GSK For You Patient Assistance — that can help with insurance navigation, copay assistance for eligible patients, nursing support, and ongoing education. More information is available at https://www.gskforyou.com.
Treatment with Exdensur is initiated and monitored by Dr. McNeil. Prior authorizations are handled in-house — patients are not asked to navigate insurance approvals on their own. This is a subcutaneous self-administered medication. After prior authorization, the prescription is sent to a specialty pharmacy that ships the medication directly to the patient. A manufacturer-sponsored nurse or office-based training visit is typically arranged for the first dose so patients are confident with self-administration before continuing at home.
A note on age: The FDA indications above may include pediatric or adolescent age groups. Optimed Immunology's clinical practice is focused on adults. If you are seeking care for a minor, please contact the office and we can advise on referral options.
Important safety note: This page is not a substitute for the FDA prescribing information. Risks, contraindications, drug interactions, and required monitoring vary by patient. The official manufacturer website (https://www.exdensur.com) provides the most current full prescribing and safety information. Treatment decisions and monitoring are individualized — please discuss with Dr. McNeil whether Exdensur is appropriate for your situation.
Donald L. McNeil, MD · Board Certified in Allergy & Immunology and Internal Medicine
This page is provided for educational purposes only and is not medical advice. If you have an emergency, call 911.