HAE Acute Treatment from Pharming Healthcare.
Ruconest is a recombinant C1 esterase inhibitor for acute HAE attack treatment. As a recombinant product (not derived from human plasma), it is an option for patients who prefer to avoid plasma-derived therapies.
Ruconest is FDA-approved for the following indications:
Ruconest is the only recombinant C1 esterase inhibitor available. It is produced in transgenic rabbits rather than pooled from human plasma, so it carries no risk of human bloodborne pathogen transmission. For that same reason it is contraindicated in patients with known or suspected rabbit allergy, which is checked before it is prescribed.
Ruconest is administered intravenously at attack onset. Self-administration is possible after appropriate training.
The manufacturer offers a patient support program — RUCONEST Solutions / RucoAssist — that can help with insurance navigation, copay assistance for eligible patients, nursing support, and ongoing education. More information is available at https://www.ruconest.com/rucoassist.
Treatment with Ruconest is initiated and monitored by Dr. McNeil. Prior authorizations are handled in-house — patients are not asked to navigate insurance approvals on their own. Infusion logistics are coordinated through trusted partner infusion providers — including Horizon Infusions, where the practice is co-located — or arranged for home infusion when appropriate. The team handles scheduling, nursing coordination, and prior-authorization renewals.
A note on age: The FDA indications above may include pediatric or adolescent age groups. Optimed Immunology's clinical practice is focused on adults. If you are seeking care for a minor, please contact the office and we can advise on referral options.
Important safety note: This page is not a substitute for the FDA prescribing information. Risks, contraindications, drug interactions, and required monitoring vary by patient. The official manufacturer website (https://www.ruconest.com) provides the most current full prescribing and safety information. Treatment decisions and monitoring are individualized — please discuss with Dr. McNeil whether Ruconest is appropriate for your situation.
Donald L. McNeil, MD · Board Certified in Allergy & Immunology and Internal Medicine
This page is provided for educational purposes only and is not medical advice. If you have an emergency, call 911.