Type 2 Inflammation Biologic (Anti-IgE) from Genentech / Novartis.
Xolair was the first targeted biologic approved in immunology. It binds free IgE and prevents IgE from triggering mast cells and basophils. Its broad utility — across allergic asthma, chronic urticaria, nasal polyps, and food allergy — makes it one of the most versatile medications in the immunology toolkit.
Xolair is FDA-approved for the following indications:
Xolair is administered subcutaneously every two or four weeks, with the interval determined by body weight and pre-treatment IgE level. It can be given in the office or as a self-injected at home for appropriate patients.
The manufacturer offers a patient support program — Genentech Access Solutions — that can help with insurance navigation, copay assistance for eligible patients, nursing support, and ongoing education. More information is available at https://www.genentech-access.com/patient.html.
Treatment with Xolair is initiated and monitored by Dr. McNeil. Prior authorizations are handled in-house — patients are not asked to navigate insurance approvals on their own. This is a subcutaneous self-administered medication. After prior authorization, the prescription is sent to a specialty pharmacy that ships the medication directly to the patient. A manufacturer-sponsored nurse or office-based training visit is typically arranged for the first dose so patients are confident with self-administration before continuing at home.
Important safety note: This page is not a substitute for the FDA prescribing information. Risks, contraindications, drug interactions, and required monitoring vary by patient. The official manufacturer website (https://www.xolair.com) provides the most current full prescribing and safety information. Treatment decisions and monitoring are individualized — please discuss with Dr. McNeil whether Xolair is appropriate for your situation.
Donald L. McNeil, MD · Board Certified in Allergy & Immunology and Internal Medicine
This page is provided for educational purposes only and is not medical advice. If you have an emergency, call 911.